硕士生导师

硕士生导师

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刘桂荣

发布时间:2019年08月08日来源:本站原创 作者:本站原创

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刘桂荣 女 1954年1月15日生

学历

1978年8月毕业于佳木斯师范 (现佳木斯大学教育学院),化学专业。

1972年8月毕业于黑龙江省富锦县第二中学 (高中)

职历

2008年2月至今

哈尔滨医科大学基因组中心 研究员

2002年2月至2008年2月

北京大学医学部微生物系 主管技师

1996年12月至2002年2月

加拿大卡尔加里大学医学院生化系 Research Fellow and Lab Manager

1995年10月至1996年11月

加拿大卡尔加里大学理学院生物系 Research Fellow

1990年7月至1995年9月

加拿大卡尔加里大学理学院生物系 Research Fellow

1978年8月至1990年6月

黑龙江省富锦市第四中学 教师

1972年9月至1975年8月

黑龙江省富锦市第六小学 教师

科研经费

1. 中国国家自然科学基金,31110103014/C010301,邀请外国科学家来华参加科研合作交流活动,2011-05至2011-12,1万元。

2. 黑龙江省自然科学基金,mutL基因自发调节遗传稳定性:在细菌进化中可能发挥的作用,2010-2012,5万元。

3. 中国国家自然科学基金,30970078,自发调节的遗传开关在细菌进化中的作用:一个沙门氏菌的模型,2010-2012,30万元。

发表

I. 原始论文(2002年以来)

1. Le Tang, Song-Ling Zhu, Xin Fang, Yong-Guo Li, Cornelis Poppe, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2019. Distinct evolutionary origins of common multi-drug resistance phenotypes in Salmonella typhimurium DT104: a convergent process for adaptation under stress. Molecular Genetics and Genomics. In press.

2. Le Tang*, Emilio Mastriani*, Yu-Jie Zhou*, Songling Zhu, Xin Fang, Yang-Peng Liu, Wei-Qiao Liu, Yong-Guo Li, Randal N. Johnston, Zheng Guo**, Gui-Rong Liu**, Shu-Lin Liu**. 2017. Differential degeneration of the ACTAGT sequence among Salmonella: a reflection of distinct nucleotide amelioration patterns during bacterial divergence, Scientific Reports. 7: 10985 | DOI:10.1038/s41598-017-11226-9.

3. Yu-Jie Zhou, Dan-Dan Zhao, Huidi Liu, Hao-Ting Chen, Jia-Jing Li, Xiao-Qin Mu, Zheng Liu, Xia Li, Le Tang, Zhan-Yi Zhao, Ji-Heng Wu, Yu-Xuan Cai, Ya-Zhuo Huang Peng-Ge Wang, Yi-Yue Jia, Pei-Qiang Liang, Xue Peng, Si-Yu Chen, Zhi-Lin Yue, Xin-Yuan Yuan, Tammy Lu, Bing-Qing Yao, Yong-Guo Li, Gui-Rong Liu, Shu-Lin Liu. 2017. Cancer killers in the human gut microbiota: diverse phylogeny and broad spectra. Oncotarget. 2017 Apr 21. doi: 10.18632/oncotarget.17319. [Epub ahead of print] PMID: 28484095.

4. Le Tang, Songling Zhu, Emilio Mastriani, Xin Fang, Yu-Jie Zhou, Yong-Guo Li, Randal N. Johnston, Zheng Guo, Gui-Rong Liu*, Shu-Lin Liu*. 2017. Conserved intergenic sequences revealed by CTAG-profiling in Salmonella: thermodynamic modeling for function prediction. Scientific Reports. 7:43565 | DOI: 10.1038/srep4356.

5. Qing-Hua Zou, Ren-Qing Li, Gui-Rong Liu, Shu-Lin Liu. 2016. Genotyping of Salmonella with lineage-specific genes: correlation with serotyping. International Journal of Infectious Diseases. 49: 134-140.

6. Chun-Xiao Wang, Song-Ling Zhu, Xiao-Yu Wang, Bailiang Li, Ye Feng, Yong-Guo Li, Randal N Johnston, Gui-Rong Liu, Jin Zhou*, Shu-Lin Liu*. 2015. Complete genome sequence of Salmonella enterica subspecies arizonae str. RKS2983. The Standards in Genomic Sciences. 10:30.

7. Bailiang Li, Yang Li, Zi-Qiao Yan, Huidi Liu, Gui-Rong Liu, Shu-Lin Liu. 2015. Profile of differentially expressed intratumoral cytokines as a signature to probe CD4+ T cell polarization and predict the immune-polarizing side effects of tamoxifen in breast cancer treatment. American Journal of Cancer Research. 5(2):726-737.

8. Le Tang, Wei-Qiao Liu, Xin Fang, Qiang Sun, Song-Ling Zhu, Chun-Xiao Wang, Xiao-Yu Wang, Kenneth E. Sanderson, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2014. CTAG-containing cleavage site profiling to delineate Salmonella into natural genetic clusters. PLoS ONE. 9(8).

9. Hong-Xia Bao, Le Tang, Lu Yu, Xu-Yao Wang, Yang Li, Xia Deng, Ang Li, Yong-Guo Li, Randal N. Johnston, Gui-Rong Liu*, Ye Feng*, Shu-Lin Liu*. 2014. Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation. BMC Microbiology. 14:157

10. Qing-Hua Zou, Ren-Qing Li, Gui-Rong Liu, Shu-Lin Liu. 2014. Comparative genomic analysis between typhoidal and non-typhoidal Salmonella serovars reveals typhoid-specific protein families. Infection, Genetics and Evolution. 26:295-302.

11. 王春晓,王晓宇,刘桂荣,刘树林。2013,72株大肠埃希菌参考菌株的基因组分型及种系发育关系,哈尔滨医科大学学报, 47(5):481-485

12. Le Tang, Chun-Xiao Wang, Song-Ling Zhu, Yang Li, Xia Deng, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2013. Genetic boundaries to delineate the typhoid agent and other Salmonella serotypes into distinct natural lineages. Genomics. 102: 331-337.

13. Le Tang, Yang Li, Xia Deng, Ang Li, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2013. Defining natural species of bacteria: clear-cut genomic boundaries revealed by a turning point in nucleotide sequence divergence. BMC Genomics. 14:489.

14. Er-Ying Zhao, Hong-Xia Bao, Le Tang, Qing-Hua Zou*, Wei-Qiao Liu, Da-Ling Zhu, Jessica Chin, Ying-Ying Dong, Yong-Guo Li, Feng-Lin Cao, Cornelis Poppe, Kenneth E. Sanderson, Randal N. Johnston, Daoguo Zhou, Gui-Rong Liu*, Shu-Lin Liu*. 2013. Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains. Molecular Genetics and Genomics. 288 (11): 549-557.

15. Ji Liu, Ji-Tao Guo, Yong-Guo Li, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2013. The type VI secretion system of Salmonella typhimurium: required for full virulence in mice. Journal of Basic Microbiology. 53(7):600-7.

16. Ye Feng, Randal N. Johnston, Gui-Rong Liu, Shu-Lin Liu. 2013. Genomic comparison between Salmonella Gallinarum and Pullorum: differential pseudogene formation under common host restriction. PLoS ONE. 8(3): e59427.

17. Zhen-Hong Liu, Yan Xu, Li-Bo Duo, Yu Liu, Zhao-Zhen Xu, Jane L. Burns, Gui-Rong Liu, Bao-Feng Yang*, Shu-Lin Liu*. 2013. Pseudomonas aeruginosa isolates of distinct sub-genotypes exhibit similar potential of antimicrobial resistance by drugs exposure. Antonie van Leeuwenhoek. 103: 797–807.

18. Ye Feng, Ji Liu, Yong-Guo Li, Feng-Lin Cao, Jin Zhou*, Gui-Rong Liu*, Shu-Lin Liu*. 2012. Inheritance of the Salmonella virulence plasmids: mostly vertical and rarely horizontal. Infection, Genetics and Evolution. 12: 1058-1063. IF:3.128

19. Ye Feng, Hua-Feng Xu, Qing-Hai Li, Si-Yao Zhang, Chun-Xiao Wang, Da-Ling Zhu, Feng-Lin Cao, Yong-Guo Li, Randal N. Johnston, Gui-Rong Liu, Jin Zhou*,Shu-Lin Liu*. 2012. Complete genome sequence of Salmonella pullorum RKS5078. J. Bacteriol. Vol. 194 (3): 744. IF:3.825

20. Qing-Hua Zou, Qing-Hai Li, Hong-Yun Zhu, Ye Feng, Da-Ling Zhu, Yong-Guo Li, Jin Zhou, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2010. SPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C. BMC Genomics. 11: 729.

21. Fang Chen, Wei-Qiao Liu, Abraham Eisenstark, Randal N. Johnston, Gui-Rong Liu*, Shu-Lin Liu*. 2010. Multiple Genetic Switches Spontaneously Regulating Bacterial Mutability. BMC Evolutionary Biology. 10:277.

22. Fang Chen, Wei-Qiao Liu, Zhen-Hong Liu, Qing-Hua Zou, Ye Wang, Yong-Guo Li, Jin Zhou, Abraham Eisenstark, Randal N. Johnston, Gui-Rong Liu, Bao-Feng Yang*, Shu-Lin Liu*. 2010. mutL as a genetic switch of bacterial mutability: turned on or off through repeat copy number changes. FEMS Microbiology Letters. 312: 126 - 312.

23. He Huang, Ye-Jun Wang, Aaron P. White, LY Deng, R Dong, Gui-Rong Liu, Shu-Lin Liu, Yue-Dan Wang. 2009. Salmonella expressing a T-cell epitope from Sendai virus are able to induce anti-infection immunity. Journal of Medical Microbiology. 58: 1236-1242.

24. Fang Chen, Cornelis Poppe, Gui-Rong Liu, Yong-Guo Li, Yi-Hong Peng, Kenneth E. Sanderson, Randal N. Johnston, Shu-Lin Liu. 2009. A Genome Map of Salmonella enterica serovar Agona: Numerous Insertions and Deletions Reflecting the Evolutionary History of a Human Pathogen. FEMS Microbiology Letters. 293: 188-195.

25. Wei-Qiao Liu, Ye Feng, Yan Wang, Qing-Hua Zou, Fang Chen, Ji-Tao Guo, Yi-Hong Peng, Yan Jin, Yong-Guo Li, Song-Nian Hu, Randal N. Johnston, *Gui-Rong Liu, *Shu-Lin Liu*. 2009. Salmonella paratyphi C: diverging from S. choleraesuis and converging with S. typhi. PLoS ONE. 4(2): e4510. *共同通讯作者

26. Ye-Jun Wang, Yan Hou, He Huang, Gui-Rong Liu , Aaron P. White, Shu-Lin Liu. 2008. Two oral HBx vaccines delivered by live attenuated Salmonella: both eliciting effective anti-tumor immunity. Cancer Letters. 263: 67-76.

27. *Liu, W.-Q., *G.-R. Liu, *J.-Q. Li, G.-M. Xu, D.-N. Qi, X.-Y. He, J. Deng, F.-M. Zhang, R. N. Johnston, S.-L. Liu. 2007. Diverse genome structures of Salmonella paratyphi C. BMC Genomics. 8: 290. *共同第一作者

28. Gong, J., W.-Q. Liu, G.-R. Liu, F. Chen, J.-Q. Li, G.-M. Xu, L. Wang, R. N. Johnston, A. Eisenstark, S.-L. Liu. 2007. Spontaneous conversion between mutL and 6bpmutL in Salmonella typhimurium LT7: association with genome diversification and possible roles in bacterial adaptation. Genomics. 90: 542-549.

29. 汪业军,侯艳,黄鹤,刘桂荣,刘树林。2007。沙门菌III型分泌蛋白融合HBx抗原介导的T细胞免疫效果观察。中华微生物学和免疫学杂志。27:719-724。

30. 刘桂荣,刘葳峤,祁丹妮,何晓燕,张凤民,刘树林。2006。鸡沙门菌基因组物理图。中华微生物学和免疫学杂志。26:965-970。刘桂荣为第一作者

31. Liu, G.-R., W.-Q. Liu, R. N. Johnston, K. E. Sanderson, S.-X. Li, S.-L. Liu. 2006. Genome plasticity and ori-ter rebalancing in Salmonella typhi. Molecular Biology and Evolution. 23 (2): 365-371. 刘桂荣为第一作者

32. Wu, K.-Y., G.-R. Liu, W.-Q. Liu, A. Q. Wang, S. Zhan, K. E. Sanderson, R. N. Johnston, S.-L. Liu. 2005. The genome of Salmonella gallinarum: distinct insertions/deletions and rare rearrangements. J. Bacteriol. 188: 4720-4727.

33. Zheng, J.-F., G.-R. Liu, W.-F. Zhu, Y-G. Zhou, S.-L. Liu. 2004. Phylogenetic clusters of Rhizobia revealed by genome structures. Science in China 47 (3): 268-278.

34. 郑君芳,刘桂荣,朱万孚,周宇光,刘树林。2004. 基因组结构揭示的根瘤菌系统发育群Rhizobia: distinct phylogenetic clusters revealed by copy number and genomic locations of rrn operons. 中国科学Science in China 33 (6): 514-524.

35. 衣美英,刘桂荣,朱永红,朱万孚,刘树林。2003. E. coli临床分离株的基因组结构分型Genome typing of clinical isolates of Escherichia coli. 中华微生物学和免疫学杂志Chinese Journal of Microbiology and Immunology. 23 (12): 941-945.

36. 郑君芳,陈文峰,刘桂荣,隋新华,朱万孚,陈文新,R. N. Johnston, 刘树林. 2003. Diversity of genome structure among rhizobia and its correlation with phylogeny. 微生物学通报Microbiology (Beijing) 30 (4): 72-76

37. Liu, G.-R., K. Edwards, A. Eisenstark, Y.-M. Fu, W.-Q. Liu, K.E. Sanderson, R.N. Johnston, and S.-L. Liu. 2003. Genomic diversification among archival strains of Salmonella typhimurium LT7. J. Bacteriol. 185 (7): 2131-2142

38. Liu, S.-L., G.-R. Liu, S.-X. Li, W.-Q. Liu, J.-F. Zheng, W.-F. Zhu, H.-X. Gu, X.-K. Guo, K. E. Sanderson, Y.-G. Zhou and R. N. Johnston. 2002. Bacterial genome structure: a molecular marker to reveal phylogenetic clusters. J. Peking Univ. [Med]. 34(5): 457-463

39. Liu, G.-R., A. Rahn, W.-Q. Liu, K. E. Sanderson, R. N. Johnston, and S.-L. Liu. 2002. The evolving genome of Salmonella pullorum. J. Bacteriol. 184 (10): 2626-2633

II. 会议摘要

1. Liu, G.-R., W.-Q. Liu, G.X. Zhao, R. N. Johnston, L. Wang, K. E. Sanderson, S.-L. Liu. Near complete conservation of endonuclease cleavage sites to define the basic phylogenetic unit of Salmonella. ASM Second Salmonella Conference. Victoria, BC, Canada, September 9-13, 2006

2. Gui-Rong Liu, Wei-Qiao Liu, Randal N. Johnston, Kenneth E. Sanderson, Shao-Xian Li, Sushma Kothapalli and Shu-Lin Liu. Genome Rearrangement in Salmonella typhi: Restructuring for ori-ter Rebalancing. WHO Sixth international Conference on Salmonella typhoid and other salmonelloses. Guilin, China, November 12 – 14, 2005

3. Gui-Rong Liu, Wei-Qiao Liu, Randal N. Johnston, Kenneth E. Sanderson, Shao-Xian Li, Shu-Lin Liu. The restructuring genomes of Salmonella: rearranging for rebalancing. The China-UK Workshop on foodborne pathogens. Beijing, China, March 8 – 10, 2005

4. Liu, S.-L., D. Qi, G.-R. Liu, W.-Q. Liu, K. E. Sanderson, and R. N. Johnston. Genome structure of Salmonella paratyphi C and its comparisons to Salmonella typhi and Salmonella typhimurium The 102nd Annual Meeting of the American Society for Microbiology, Salt Lake City, Utah, May 19-23, 2002.

5. Liu, W.-Q., G.-R. Liu, D. Qi, S.-L. Liu, R. N. Johnston, and K. E. Sanderson. Salmonella paratyphi B: genomic divergence and evolution. The 102nd Annual Meeting of the American Society for Microbiology, Salt Lake City, Utah, May 19-23, 2002.

6. Liu, G.-R., A. B. Schryvers, M. Rahimkhany, R. N. Johnston, K. E. Sanderson, S.-L. Liu. Genome structures of Neisseria meningitides: diversity and conservation. The 102nd Annual Meeting of the American Society for Microbiology, Salt Lake City, Utah, May 19-23, 2002.

7. Liu, G.-R., K. Edwards, A. Eisenstark, W.-Q. Liu, S. Porwollik, M. McClelland, K.E. Sanderson, R.N. Johnston, and S.-L. Liu. Diverse genomes among archival Salmonella typhimurium LT7 mutants. The 102nd Annual Meeting of the American Society for Microbiology, Salt Lake City, Utah, May 19-23, 2002.

8. Liu, S.-L., G.-L. Liu, K. E. Sanderson, and R. N. Johnston. Bacterial genome structure as a phylogenetic marker. The 8th International Small Genomes Conference, Lake Arrowhead, California, USA, September 25-28, 2000

9. Liu, S.-L., V. Stewart, G.-R. Liu, Z.-H. Fang, R. N. Johnston and K. E. Sanderson. A genome map of Klebsiella oxytoca and population genome structure of Klebsiella spp. The 100th Annual Meeting of the American Society for Microbiology, Los Angeles, CA, May 21-24, 2000.

10. Liu, S.-L., G.-L. Liu, K. E. Sanderson, and R. N. Johnston. Salmonella typhimurium: unique features in genome structure to account for speciation. The 8th UA/UC biennial international conference on infectious diseases. Panorama, BC, Canada, May 14-17, 2000