孙斌 博士生导师。
教育经历:2008.09 – 2015.06 华中科技大学 生物药学,本硕
2015.08 – 2019. 12 University of Kentucky, 计算生物化学,博士
工作经历:2019.12 – 2021.09 Stritch Medical Center Loyola University Chicago, 博士后
2021.12 – 至今, 哈尔滨医科大学,特聘教授
研究方向:利用多尺度计算化学(multi-scale computational methods)研究生物大分子间相互作用的分子机理。特别是对Ca2+信号诱导的蛋白/蛋白相互作用,以及Ca2+, K+等跨膜离子通道有浓厚的兴趣。近5年来,以第一作者在JCTC, JCIM, IJMS 等国际主流期刊发表SCI论文7篇。谷歌学术论文引用次数>500, 他引h-index 12.
承担课题:哈尔滨医科大学高层次优秀青年人才启动基金。
发表文章:
Bin Sun et al., Thermodynamics of cation binding to the sarco-endoplasmic reticulum calcium ATPase pump and impacts on enzyme function, 2019, J. Chem. Theory. Comput. (IF = 6.0)
Bin Sun et al., The non-canonical interaction between calmodulin and calcineurin contributes to the differential regulation of plant-derived calmodulins on calcineurin, 2021, J. Chem. Inf. Model. (IF = 4.9)
Bin Sun et al., Assessing the role of calmodulin's linker flexibility in target binding, 2021, Int. J. Mol. Sci. (IF = 5.9)
Bin Sun et al., Molecular basis of S100A1 activation and target regulation within physiological cytosolic Ca2+ levels, 2020, Front. Mol. Biosci. (IF = 5.2)
Bin Sun et al, Simulation-Based Characterization of Electrolytes and Small Molecule Diffusion in OrientedMesoporous Silica Thin Films. Computational Materials, Chemistry, and Biochemistry: From BoldInitiatives to the Last Mile. 2021 Springer Series in Materials Science, Springer (Book Chapter)
Bin Sun et al., Electrostatic control of calcineurin's intrinsically-disordered regulatory domain binding to calmodulin, 2018, Biochimica et Biophysica Acta (BBA)-General Subjects. (IF=3.8)
Bin Sun et al., Calmodulin-Calcineurin Interaction beyond the Calmodulin-Binding Region Contributes to Calcineurin Activation, 2019, Biochemistry (IF=3.2)
JF Huang, Bin Sun Yuan Yao and Junjun Liu. Fast and Reliable Thermodynamic Approach for Determining the Protonation State of the Asp Dyad, 2017, J. Chem. Inf. Model. (IF=4.9)
K Immadisetty, Bin Sun and Peter Kekenes-Huskey, Structural determinants of calcium binding beyond the EF-hand binding site: a study of alpha parvalbumins, 2021, J. Phys. Chem. B., (IF=2.99)
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联系方式:17786743295 ; binsun@hrbmu.edu.cn