生物制药学教研室成立于2003年，现有教师7人，其中教授3人、副教授３人，讲师１人。具有博士学位6人。教研室自成立以来，在学科建设、科学研究及人才培养等方面均取得长足发展。现面向药学及临床药学本科生开设《生物技术制药》及《药学分子生物学》两门课程，每门课程教学任务各54学时。本教研室教师作为主编及参编《实用RNAi技术》等相关著作4部，作为副主编或编委参与编写规划教材6本。培养硕士研究生97名，博士研究生35名。指导的研究生曾多次荣获省、校级优秀毕业论文。教研室自成立以来，已发表SCI收录论文50余篇，承担国家自然科学基金项目10余项，授权发明专利6项，此外，生物制药学教研室多次荣获哈医大药学院优秀教研室称号。随着“十三五”的开始，生物制药学教研室全体教师正以崭新面貌积极迎接新的挑战，不断完善及提升自我。

生物制药学教研室全体教师

[教材编写]

副主编卫计委“十二五”、“十三五”规划教材《生物技术制药》（唐晓波）、副主编专科教育教材《生理学》（ 谷瑞民）、参编英文版教材《生理学》（谷瑞民）、参编卫生部“十二五”规划教材《医学英语基本词汇学习手册》（唐晓波）、参编卫计委“十三五”规划教材配套教材《生物技术制药实验指导》（王爽）。

[主要著作]

1、主编：人民卫生出版社2009年 全国卫生专业技术资格考试习题集丛书《药学(中级)精选习题解析》

2、专家组成员：中国科学技术出版社2009年《2008-2009年药学学科发展报告》

3、主编：人民军医出版社 2008年 《生物化学学习纲要》

4、编译：人民卫生出版社 2006年 《实用RNAi技术》

5、编委：人民卫生出版社 2004年《离子通道药理学》

[科研方向］

1、脑出血发病机制研究；

2、肾小管髓袢升支粗段及远曲小管K+，Cl-活性的调控相关研究；

3、肿瘤侵袭转移机制研究；

4、肺动脉高压发病机制研究。

[授权的发明专利]

1．唐晓波;朱大岭;刘海英;杨 微;武正华;王志刚;于 磊;纪宏宇;戴丽娟：一种CYP1A2多肽，发明专利，专利号：ZL 2006 1 0010342.7，授权公告日：2008.11.19

2、唐晓波；朱大岭；刘海英；杨 微；武正华；郭守利：一种CYP3A4多肽，发明专利，专利号：ZL200610010543.7，授权公告日：2010.10.13

3. 唐晓波，李淑珍，李郁梅，鄢成伟，陈莉，李新禹，单瑞辉， 于学薇：一种抗血管内皮细胞生长因子受体2/抗CD3双特异单链抗体，发明专利，专利号：ZL201110129295.9，授权公告日：2013.03.27

4、唐晓波，李淑珍，单瑞辉，陈莉，李新禹，吴红：一种肝细胞癌相关蛋白HSP70的表达纯化方法，发明专利，专利号：ZL201110143695.5，授权公告日：2013.08.07

5、朱大岭；唐晓波；武正华；王志刚；纪宏宇；于磊：分泌人羧酸酯酶2单克隆抗体的杂交瘤细胞株及人羧酸酯酶2的单克隆抗体，发明专利，专利号：ZL 2006 1 0009931.3，授权公告日：2008.09.17，证书号：第428785号

6、朱大岭；唐晓波；杨 微；刘海英；武正华；吴红：一种CYP4A11多肽，发明专利，专利号：ZL 2006 1 0010485.8，授权公告日：2008.08.13，证书号：第419866号

[主要论文]

1、Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER.: Chronic Hypoxia Activates Lung 15-Lipoxygenase, Which Catalyzes Production of 15-HETE and Enhances Constriction in Neonatal Rabbit Pulmonary Arteries . Circulation Research.2003 92: 992-1000

2、Lv C, Ye H, Tang X and Zhu D：A role of ERK1/2 in hypoxic pulmonary vasoconstriction evoked by 15-HETE stimulation. Canadian Journal of Physiology and Pharmacology. 2006 84：1-9 2.557

3、Ruimin Gu, Jing Wang, Yunhong Zhang, Wennan Li,Ying Xu,Hongli Shan,Wen-Hui Wang and Baofeng Yang Adenosine stimulates the basolateral 50pS K channels in the thick ascending limb of the rat kidney. Am J Physiol Renal Physiol. 2007, 293: F299-F305.

4、Ruimin Gu, Yan Jin, Yuanyuan Zhai, Lei Yang, Chengbiao Zhang, Wennan Li, Lijun Wang, Shumin Kong, Yunhong Zhang, Baofeng Yang and Wen-Hui Wang，PGE2 inhibits basolateral 50Ps potassium channels in the thick ascending limb of the rat kidney. Kidney Int. 2008, 74: 478-485.

5、Gu RM, Yang L, Zhang Y, Wang L, Kong S, Zhang C, Zhai Y, Wang M, Wu P, Liu L, Gu F, Zhang J, Wang WH. CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb. Kidney Int. 2009, 76: 849-856.

6、Guo L, Tian H, Liu Y, Wang J, Guo S, Tang X, Zhu D：Subacute hypoxia decreases voltage-gated potassium channel subunit Kv 3.4 expression and whole-cell K+ current by endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells. European Journal of Pharmacology. 2008 10; 587(1-3):187-95

7、Zheng X， Liang S, Chen L, Zhang S，Tang X, Zhu D： The role of the Ca2+ in the process of 15-HETE induced hypoxia pulmonary vasoconstriction. European Journal of Pharmacology. 2008 601：16-22

8、Tang X, Zhang R, Wang Z, Yu L, Li S and Zhu D： Influence of the 15-HETE on Cytosolic [Ca2+]i of the Rabbit Pulmonary Artery Smooth Muscle Cells. BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY. 2008 51(2) : 281-286

9、Liu Y, Lv C, Ye H, Meng L, Tang X and Zhu D：15-LO mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. Pathology 2009 41(5):493-500

10、Chu X, Tang X, Guo L, Bao H, Zhu D：Subacute hypoxia suppresses Kv1.5 channel expression through endogenous 15-HETE in rat pulmonary artery. Prostaglandins & Other Lipid Mediators 2009 88(1-2):42-50

11、Li Y, Wang Z, Liang D, Liang S, Zhu D：15-HETE suppresses K+ channel activity and inhibits apoptosis in rat pulmonary artery smooth muscle cells Apoptosis 2009 14(1):42-51

12、Guo L, Tang X, Chu X, Zhu D：Roles of PKC in the process of 15-HETE induced pulmonary artery vasoconstriction. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2009;80(2-3):115-23.

13、Ma J, Liang S, Wang Z, Jiang J, Zhang L, Zheng J, Yu L and Zhu D：ROCK Pathway Participates in the Processes that 15-Hydroxyeicosatetraenoic Acid (15-HETE) Mediated the Pulmonary Vascular Remodeling Induced by Hypoxia in Rat. Journal of Cellular Physiology. 2010 222(1):82-94

14、Wang S, Wang Y, Jiang J, Wang R, Li L, Qiu Z, Wu H, Zhu D：15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway. Prostaglandins and Other Lipid Mediators. 2010;91(1-2):51-60

15、Wang Y, Liang D, Wang S, Qiu Z, Chu X, Chen S, Li L, Nie X, Zhang R, Wang Z, Zhu D：Role of the G-protein and tyrosine kinase - Rho/ROK pathways in 15-hydroxyeicosatetraenoic acid (15-HETE) induced pulmonary vasoconstriction in hypoxic rats. J BIOCHEM. 2010 May;147(5):751-64.

16、Han W, Liu Y, Lv C, Zhu D：ERK1/2 Signaling Pathways Is Involved In 4-AP-induced Normoxic Rat Pulmonary Vasoconstriction. European Journal of Pharmacology. 2007;569（1-2 ）：138-144

17、YU W，Huang L，Liu Y，YU H，Zhu D：The Role of CYP2D6 in metabolism of Sodium Ozagrel. European Journal of Pharmacology. 2007 573 (1-3):55-9.

18、Wang Z , Tang X , Li Y, Lv C, Guo L, Zheng X, Zhu D：20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. European Journal of Pharmacology. 2008 24;588(1):9-17

19、Tang X, Wu H, Wu Z, Wang G, Zhu D：Carboxylesterase 2 is downregulated in colorectal cancer with the disease progression. Cancer Investigation. 2008 26（2）：178－181

20、Zhang J, Tang X, Lv C, Zhu D：Staurosprine aglycone bilaterally regulates ERK1/2 phosphorylation in rat pulmonary artery smooth muscle cells. Canadian Journal of Physiology and Pharmacology. 2008 86: 1-7

21、Qu F, Liu Y, Zhu D： Construction of tissue-engineered cartilage with BMP7 gene-transfected chondrocytes. J Int Med Res.2008 36(4):837-47

22、Wang W, Adachi M, Zhang R, Zhou J, Zhu D.：A Novel Combination Therapy With Arsenic Trioxide and Parthenolide Against Pancreatic Cancer. Pancreas. 2009 38（4）：114-123.

23、Cai L, Zhang G, Tong X, You Q, An Y, Wang Y, Guo L, Wang T, Zhu D, Zheng J：Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA .European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010 148(1):73-80.

24、W Shi, N Cui, Z Wu, Y Yang, S Zhang, H Gai, Zhu D, Jiang C. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling. J Biol Chem. 2010 29;285(5):3021-9.

25、Jun Ma, Lei Zhang, Shanshan Li, Lei Guo, Shu-Lin Liu, Cui Ma, Weiyang Li J.R. Falck, Vijay L. Manthati, D. Sudarshan Reddy, Meetha Medhora, Elizabeth R. Jacobs and Daling Zhu：8,9-EET analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. Experimental Cell Research. 2010 15;316(14):2340-53

26、Lei Guo, Xiaobo Tang, Xiaojie Chu, Zhigang Wang, Lei Zhang, Daling Zhu: Hypoxia suppresses Kv 2.1 channel expression through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial. Journal of Physiological Sciences J Physiol Sci. 2010 60(5):373-81

27、Shanshan Li, Yajuan Ran, Xiaodong Zheng, Xiaoping Pang, Zhigang Wang, Weiyang Li, and Daling Zhu: 15-HETE Mediates Sub-acute Hypoxia-induced TRPC Expression and Elevated Intracellular Ca2+ in rat distal pulmonary arterial myocytes Prostaglandins and Other Lipid Mediators . 2010 93(1-2):60-74.

28、Zhang S, Liu Y, Guo S, Zhang J, Chu X, Jiang C, Zhu D：Vasoactive intestinal polypeptide relaxes isolated rat pulmonary artery rings through two distinct mechanisms. J Physiol Sci. 2010 60(6):389-97

29、Lei Zhang, Jun Ma, Lei Guo, Yajuan Ran, Ruifang Wang, Shuling Lui, Chun Jiang, and Daling Zhu：15-Hydroxyeicosatetraenoic Acid (15-HETE) Protects Pulmonary Artery Smooth Muscle Cells against Apoptosis via HSP90 Life Science Life Sci. 2010,14;87(7-8):223-231

30、Lu C, Li XY, Hu Y, Rowe RG, Weiss SJ. MT1-MMP controls human mesenchymal stem cell trafficking and differentiation. Blood. 2010,115(2):221-9.

31、Zhigang Wang, Tong Yao, Zhenyuan Song. Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease.J. Lipid Res. 2010, 51: 3158-65.

32、Zhigang Wang, Tong Yao, Maria Pini, Zhanxiang Zhou, Giamila Fantuzzi, Zhenyuan Song. Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease.Am J Physiol Gastrointest Liver Physiol. 2010, 298(5): G634-42.

33、Zhigang Wang, Tong Yao, Zhenyuan Song. Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. Alcoholism: Clinical and Experimental Research 2010, 34(3): 471-8.

34、Zhigang Wang, Tong Yao, Zhenyuan Song. Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice.Experimental Biology and Medicine. 2010, 235(11):1347-55.

35、Wang S, Cao W, Xing H, Chen YL, Li Q, Shen T, Jiang C, Zhu D： The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells. Journal of Receptors and Signal Transduction. 2011 ,31(1):45-52

36、Wang M, Sui H, Li W, Wang J, Liu Y, Gu L, Wang WH, Gu RM. Stimulation of A2a adenosine receptor abolishes the inhibitory effect of arachidonic acid on the basolateral 50-pS K channel in the thick ascending limb. Am J Physiol Renal Physiol. 2011, 300(4): F906-913.

37、Stimulation of Ca2+-sensing receptor inhibits the basolateral 50-pS K channels in the thick ascending limb of rat kidney.Kong S, Zhang C, Li W, Wang L, Luan H, Wang WH, Gu R.

Biochim Biophys Acta. 2012 Feb;1823(2):273-81.

38、Wang L, Li W, Kong S, Wu P, Zhang C, Gu L, Wang M, Wang W, Gu R. Insulin-like growth factor-1 (IGF-1) inhibits the basolateral Cl channels in the thick ascending limb of the rat kidney.

Biochim Biophys Acta. 2012 Jul;1823(7):1163-9. d

39、Li S, Ran Y, Zhang D, Chen J, Li Sh, Zhu D. MicroRNA-138 plays a role in hypoxic pulmonary vascular remodeling by targeting Mst1. Biochemical Journal. 2013, 452 (2): 281-91. 40、Sun Xiaojiao, Gao Xu, Zhou Lingyun, Sun Lijun, Lu Changlian. PDGF-BB-induced MT1-MMP expression regulates proliferation and invasion of mesenchymal stem cells in 3-dimensional collagen via MEK/ERK1/2 and PI3K/AKT signaling. Cell Signal. 2013 Feb 13;25(5):1279-1287.

41、Lu C, Sun X, Sun L, Sun J, Lu Y, Yu X, Zhou L, Gao X. Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane. J Cell Physiol. 2013 Sep;228(9):1827-33.

42、Song S, Wang S, Ma J, Yao L, Xing H, Zhang L, Liao L, Zhu D. Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway. Exp Cell Res. 2013;319(13):1973-1987.

43、Li S, Ran Y, Zhang D, Chen J, Li Sh, Zhu D. MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K+ channel in arterial smooth muscle cells. Journal of Cellular Biochemistry. 2014, 115 (6):1196-205.

44、Sugumaran PK, Wang S, Song S, Nie X, Zhang L, Feng Y, Ma W, Zhu D.15-oxo-Eicosatetraenoic acid prevents serum deprivation-induced apoptosis of pulmonary arterial smooth muscle cells by activating pro-survival pathway. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2014;90(4):89-98. IF.3.155

45、Li S, Li Q, Lv X, Liao L, Yang W, Li S, Lu P, Zhu D. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats. J Pharmacol Sci. 2015 Jul;128(3):108-15.

46、Liang Liu, Shu Wang, Ruobing Xu, Jian Zheng, Jiaxin Tang , Xiaobo Tang, Dongwei Zhang.Experimental intracerebral haemorrhage: description of a semi-coagulated autologous blood model in rats，Neurological Research，Volume 37, Issue 10 (October 2015), 874-879

47、Sun L, Lin P, Qin Z, Liu Y, Deng LL, Lu C. Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation. Exp Biol Med (Maywood). 2015 Nov;240(11):1434-45.

48、Fan L, Wang X, Zhang D, Duan X, Zhao C, Zu M, Meng X, Zhang C, Su XT, Wang MX, Wang WH, Gu R. Vasopressin-induced stimulation of the Na(+)-activated K(+) channels is responsible for maintaining the basolateral K+ conductance of the thick ascending limb (TAL) in EAST/SeSAME syndrome. Biochim Biophys Acta. 2015 Nov;1852(11):2554-62.

49、Wang S, Cao W, Xing H, Chen YL, Li Q, Shen T, Jiang C, Zhu D.Activation of ERK pathway is required for 15-HETE-induced angiogenesis in human umbilical vascular endothelial cells. J Recept Signal Transduct Res. 2016;36(3):225-32.

50、Jian Zheng, Zhen Liu, Weishan Li, Jiaxin Tang, Dongwei Zhang, and Xiaobo Tang. Lithium post-treatment confers neuroprotection through glycogen synthase kinase-3beta inhibition in intracerebral hemorrhage rats. Journal of Neurosurgery, [epub ahead of print October 14, 2016. DOI: 10.3171/2016.7.JNS152995].

51、Ruobing Xu, Shu Wang, Weishan Li, Zhen Liu, Jiaxin Tang, and Xiaobo Tang. 12/15-Lipoxygenase metabolite of arachidonic acid activates peroxisome proliferator-activated receptor γ: a possible neuroprotective effect in the brain of experimental intracerebral hemorrhage, Journal of Neurosurgery, [epub ahead of print October 14, 2016. DOI: 10.3171/2016.7.JNS1668].

52、Qin Z, Feng J, Liu Y, Deng L, Lu C. PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation. Tumor Biology. 2016 Jan; 37(1): 591-9.

53、Li S, Chen S, Yang W, Liao L, Li S, Li J, Zheng Y, Zhu D. Allicin relaxes isolated mesenteric arteries through activation of PKA-KATP channel in rat. Recept Signal Transduct. 2016 Apr 6:1-8. [Epub ahead of print].

[联系方式]

联系人：唐晓波 联系电话：0451-86687074

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